Grade of injury, not initial management, is associated with unplanned interventions in liver injury

Vascular injury associated with extremity trauma: initial diagnosis and management.

Vascular injury associated with extremity trauma occurs in <1% of patients with long bone fracture, although vascular injury may be seen in up to 16% of patients with knee dislocation. In the absence of obvious signs of vascular compromise, limb-threatening injuries are easily missed, with potentially devastating consequences. A thorough vascular assessment is essential; an arterial pressure in...

SLCO1B1 *15 haplotype is associated with rifampin-induced liver injury.

The organic anion transporting polypeptide 1B1 (OATP1B1, encoded by SLCO1B1) plays an important role in the transport of endogenous and xenobiotic compounds, such as bile acids and rifampin. In this study, the association between OATP1B1 polymorphisms and rifampin hepatotoxicity was investigated using integrated population genetic analysis and functional studies. A total of 273 unrelated patien...

CYP2E1 is not involved in early alcohol-induced liver injury.

The continuous intragastric enteral feeding protocol in the rat was a major development in alcohol-induced liver injury (ALI) research. Much of what has been learned to date involves inhibitors or nutritional manipulations that may not be specific. Knockout technology avoids these potential problems. Therefore, we used long-term intragastric cannulation in mice to study early ALI. Reactive oxyg...

modified perihepatic packing; a creative and beneficial method for management of high grade liver injury

objective: to evaluate the efficacy of modified perihepatic packing (mphp) in reducing the rate of re-bleeding rate after packing removal. methods: this was an experimental study being performed in shiraz animal laboratory. high grade liver parenchymal injury was induced in 30 transgenic australian rabbits which were then divided into two groups. group a (control) included 14 and group b (exper...

The Assessment and Management of Chemotherapy Associated Liver Injury